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Safety Data Sheet

GHS Compliant Document

AvoBio
Molecular Biology Reagents
Product: pUC19
Catalog #: P001
Revision: January 9, 2026

1Identification

Product Name

pUC19

Catalog Number

P001

Product Use

Research Use Only (RUO)

Product Category

Cloning Vector - Plasmid DNA

Manufacturer/Supplier

AvoBio Inc.

Seattle, WA, United States

Email: [email protected]

Phone: +1 (800) 555-0123

Emergency Contact

24-Hour Emergency: +1 (800) 555-0199

2Hazard Identification

GHS Classification

This product is not classified as hazardous according to GHS criteria.

Label Elements

No GHS hazard pictograms required.

Signal Word

None

Hazard Statements

Not a hazardous substance or mixture.

Precautionary Statements

  • • Handle with standard laboratory safety practices
  • • Wear appropriate personal protective equipment
  • • Avoid release to the environment

Other Hazards

This product contains recombinant DNA. Handle according to institutional biosafety guidelines. May contain antibiotic resistance genes. Dispose of according to local regulations.

3Composition/Information on Ingredients

ComponentCAS NumberConcentration
Plasmid DNA (pUC19)N/A (Biological)Variable
TE Buffer (Tris-EDTA)N/A (Mixture)Balance
- Tris Base77-86-110 mM
- EDTA60-00-41 mM

Vector size: 2,686 base pairs

4First-Aid Measures

Inhalation

Move to fresh air. If symptoms persist, seek medical attention.

Skin Contact

Wash with soap and water. Remove contaminated clothing.

Eye Contact

Rinse with water for at least 15 minutes. Seek medical attention if irritation persists.

Ingestion

Rinse mouth with water. Do not induce vomiting. Seek medical attention if symptoms occur.

Most Important Symptoms

No significant symptoms expected under normal use conditions.

5Fire-Fighting Measures

Suitable Extinguishing Media

Water spray, alcohol-resistant foam, dry chemical, carbon dioxide (CO2).

Unsuitable Extinguishing Media

None known.

Special Hazards

May emit toxic fumes under fire conditions. Combustion products may include carbon oxides.

Firefighter Protection

Wear self-contained breathing apparatus and protective clothing.

6Accidental Release Measures

Personal Precautions

Wear appropriate protective equipment. Avoid contact with skin and eyes.

Environmental Precautions

Prevent release to the environment. This product contains recombinant DNA material.

Containment and Cleanup

  • • Absorb spillage with inert absorbent material
  • • Decontaminate area with 10% bleach solution
  • • Collect in appropriate containers for disposal
  • • Dispose of according to local regulations

7Handling and Storage

Precautions for Safe Handling

  • • Use aseptic technique when handling
  • • Avoid creating aerosols
  • • Wear appropriate personal protective equipment
  • • Handle in a biosafety cabinet when possible
  • • Do not eat, drink, or smoke when using this product

Storage Conditions

  • • Store at -20°C for long-term storage
  • • Stable at 4°C for short-term storage (up to 1 month)
  • • Avoid repeated freeze-thaw cycles
  • • Keep container tightly closed
  • • Protect from light

Shipping Condition

Shipped on dry ice or cold packs

8Exposure Controls/Personal Protection

Exposure Limits

No occupational exposure limits established.

Engineering Controls

Work in a well-ventilated area. Use biosafety cabinet for aerosol-generating procedures.

Personal Protective Equipment

Eye Protection

Safety glasses or goggles

Skin Protection

Lab coat and disposable gloves

Respiratory Protection

Not normally required

Hand Protection

Nitrile or latex gloves

9Physical and Chemical Properties

AppearanceClear to slightly turbid liquid
ColorColorless
OdorOdorless
pH8.0 (in TE buffer)
Boiling Point~100°C
Flash PointNot applicable
SolubilityWater soluble
Density~1.0 g/mL

10Stability and Reactivity

Reactivity

No dangerous reactions known under normal conditions.

Chemical Stability

Stable under recommended storage conditions.

Conditions to Avoid

Extreme temperatures, repeated freeze-thaw cycles, nuclease contamination.

Incompatible Materials

Strong oxidizers, nucleases, extreme pH conditions.

Hazardous Decomposition Products

Carbon oxides under combustion conditions.

11Toxicological Information

Acute Toxicity

No data available. Expected to have low toxicity.

Skin Corrosion/Irritation

Not expected to be irritating.

Eye Damage/Irritation

May cause mild irritation.

Sensitization

Not known to be a sensitizer.

Carcinogenicity

Not listed as carcinogen by IARC, NTP, or OSHA.

12Ecological Information

This product contains recombinant DNA. Do not release to the environment. Inactivate before disposal by autoclaving or chemical treatment.

Ecotoxicity

No ecotoxicity data available.

Persistence and Degradability

DNA is biodegradable. Readily inactivated by nucleases in the environment.

Bioaccumulative Potential

Not expected to bioaccumulate.

13Disposal Considerations

Important

This product contains recombinant DNA and must be properly inactivated before disposal.

Disposal Methods

  • • Autoclave at 121°C for 30 minutes, or
  • • Treat with 10% bleach solution for 30 minutes
  • • Dispose of as biohazardous waste according to institutional guidelines
  • • Follow local, state, and federal regulations

Contaminated Packaging

Dispose of as biohazardous waste. Do not reuse containers.

14Transport Information

This product is not regulated as dangerous goods for transportation.

UN Number

Not applicable

UN Proper Shipping Name

Not regulated

Transport Hazard Class

Not applicable

Packing Group

Not applicable

Special Precautions

Ship on dry ice or cold packs to maintain product stability. Mark package with "Keep Frozen" or "Keep Cold" as appropriate.

15Regulatory Information

US Federal Regulations

This product is subject to NIH Guidelines for Research Involving Recombinant DNA Molecules.

TSCA Status

Biological materials are exempt from TSCA inventory requirements.

SARA 311/312

Not classified as hazardous.

California Prop 65

This product does not contain chemicals known to the State of California to cause cancer or reproductive toxicity.

International Regulations

Check local regulations for import/export requirements for recombinant DNA materials.

16Other Information

Revision Date

January 9, 2026

Version

1.0

Disclaimer

The information provided in this Safety Data Sheet is correct to the best of our knowledge at the date of publication. The information is designed only as guidance for safe handling, use, processing, storage, transportation, disposal and release. It should not be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process.

Abbreviations

GHS - Globally Harmonized SystemIARC - Int. Agency for Research on CancerNTP - National Toxicology ProgramOSHA - Occupational Safety and Health Admin.TSCA - Toxic Substances Control ActSARA - Superfund Amendments & Reauthorization Act

AvoBio Inc.

Seattle, WA | [email protected] | www.avobio.com

SDS-P001 | Version 1.0 | January 9, 2026